Lawesson's Reagent

Lawesson's Reagent

Lawesson's Reagent is a highly efficient sulfurization reagent trusted by pharmaceutical, fine chemical, and research industries worldwide. Thionation reagent for its excellent thionation capability, high reaction selectivity, and broad substrate compatibility, it enables chemists to achieve reliable sulfur-containing compound synthesis with improved reaction efficiency and product quality.
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Ethanol CAS 19172-47-5

Product Overview

 

Lawesson's Reagent is a phosphorus-sulfur organic compound widely used as a sulfur transfer reagent in organic synthesis. It is particularly effective for converting carbonyl groups such as ketones, aldehydes, amides, esters, and lactones into their corresponding sulfur-containing derivatives. Due to its excellent reactivity and selectivity, thionation reagent has become an essential material in pharmaceutical intermediates, agrochemical intermediates, specialty chemicals, and advanced organic synthesis applications.
As modern drug discovery and fine chemical manufacturing increasingly require sulfur-containing molecules, thionation reagentprovides chemists with a reliable and efficient solution for thionation reactions while minimizing unwanted side reactions.

 

Product Description

Features: Trusted Across Advanced Chemical Synthesis

Lawesson's Reagent is recognized for its exceptional sulfurization efficiency and broad applicability across numerous organic transformations. It can effectively replace oxygen atoms in carbonyl compounds with sulfur atoms under relatively mild reaction conditions.
The reagent demonstrates excellent compatibility with various functional groups, allowing selective sulfur incorporation without significantly affecting other reactive sites within the molecule. This feature is especially valuable when synthesizing complex pharmaceutical intermediates and specialty chemicals.
Thionation reagent's high reaction efficiency often contributes to improved product yields, reduced reaction times, and simplified downstream purification processes.

Advantages: Supporting High-Value Chemical Manufacturing

Compared with alternative sulfurization reagents, Lawesson's Reagent offers superior selectivity and operational convenience. Many organic synthesis reactions can be completed under moderate temperatures, reducing energy consumption and minimizing thermal degradation of sensitive compounds.
The reagent's versatility allows manufacturers and research laboratories to use a single sulfurization solution across multiple reaction pathways. This flexibility helps reduce inventory complexity and streamline production workflows.
Strict quality control ensures consistent purity and batch-to-batch performance, supporting reproducible results in both laboratory-scale and industrial-scale applications.

Benefits: Maximizing Efficiency and Product Quality

For pharmaceutical manufacturers, Lawesson's Reagent enables the efficient preparation of sulfur-containing drug intermediates, heterocyclic compounds, and active pharmaceutical ingredient (API) building blocks. The resulting improvement in reaction reliability can reduce development time and manufacturing costs.
For specialty chemical producers, the reagent provides a practical route to high-value sulfur-containing molecules with enhanced functional properties. Its high selectivity helps minimize by-products, resulting in cleaner reactions and higher-quality final products.
Researchers also benefit from greater synthetic flexibility, allowing the exploration of new sulfur-based molecular structures and innovative chemical applications.

Evidence: Proven Performance in Organic Synthesis

Lawesson's Reagent has been extensively utilized in academic research, pharmaceutical development, and industrial organic synthesis for decades. Numerous peer-reviewed studies and commercial manufacturing processes rely on its ability to efficiently convert carbonyl compounds into thiocarbonyl derivatives.
Its continued use across pharmaceutical intermediates, fine chemicals, and specialty chemicals industries demonstrates its effectiveness, reliability, and value as one of the most established sulfurization reagents available today.

 

Product Specifications

 

Product Name

Lawesson's Reagent

CAS NO.

19172-47-5

Molecular Formula

C₁₄H₁₄O₂P₂S₄

Molecular Weight

404.47

Density

Approx. 1.50 g/cm³

Purity

≥98.0%

Melting Point

228–230°C

Flash Point

Not Available

UN Number

Not Classified

Packaging

1 KG / 5 KG / 25 KG Fiber Drum or Customized

Colour

Light Yellow to Yellow

HS Code

2931900090

EINECS

242-855-4

Appearance

Light Yellow to Yellow Crystalline Powder

 

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Contact XIMA today for the latest pricing, COA, TDS, MSDS, packaging options, and customized supply solutions. Our experienced team can help you secure high-quality Lawesson's Reagent with stable purity, professional export support, and dependable global delivery.

 

FAQ

 

Q1: What is Lawesson's Reagent mainly used for?

A1: Lawesson's Reagent is primarily used as a sulfurization reagent for converting carbonyl compounds into sulfur-containing derivatives in pharmaceutical, fine chemical, and organic synthesis applications.

Q2: Why is Lawesson's Reagent popular in pharmaceutical synthesis?

A2: It offers high selectivity, excellent sulfur transfer efficiency, and compatibility with various functional groups, making it highly effective for preparing sulfur-containing pharmaceutical intermediates.

Q3: What types of compounds can be transformed using Lawesson's Reagent?

A3: It is commonly used to convert ketones, aldehydes, amides, esters, lactones, and related carbonyl-containing compounds into corresponding sulfur analogues.

Q4: Is Lawesson's Reagent suitable for laboratory and industrial use?

A4: Yes. It is widely utilized in both research laboratories and commercial-scale manufacturing due to its reliable performance and reproducible reaction outcomes.

Q5: How should Lawesson's Reagent be stored?

A5: It should be stored in a cool, dry, and well-ventilated environment away from moisture, oxidizing agents, and direct sunlight. Containers should remain tightly sealed.

Q6: Can technical documentation be provided?

A6: Yes. We can provide COA, TDS, MSDS, packing information, and export documentation required for international shipments and regulatory compliance.

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